Wyatt DLS Dynamic Light Scattering DynaPro PlateReader III WPR3-02

Wyatt DLS Dynamic Light Scattering DynaPro PlateReader III WPR3-02
INCLUDES Dynamics Software v8.0.0.89

PN: WPR3-02
MFG Date: 2/23

Condition:  Late model, lightly used instrument.  Updated to the latest firmware, and the last PM was performed on 3/24.  Includes PC with activated Dynamics v8.0.0.89(security option not included). Original activation key and software installer are included on the desktop so the user can place on a portable drive for backup purposes.

 Includes:

• Wyatt DynaPro PlateReader III instrument (WPR3-02)
• Laptop w/ installed Dynamics v8.0.0.89 software(security option NOT included, NOT 21 CFR 11 Compliant)
  
• DynaPro III User Manual (Digital)
• 9mm plate insert (installed in instrument)
• 900149 Hardware Kit w/ 7.5mm plate insert
• Nitrogen Purge Connector
• TP Link Switch

High-throughput, automated dynamic light scattering.

The DynaPro Plate Reader III provides unparalleled levels of productivity and flexibility for the most demanding nanoparticle sizing and protein aggregation tasks such as biotherapeutic formulation, screening of promiscuous inhibitors, and optimization of protein crystallization conditions. Measurements are performed in situ with no fluid transfer. Select from industry-standard 96-, 384- or 1536-microwell plates.

(Specs from manufacturer)

Measurements

• Nanoparticle Size Range (R_h, by DLS) - 0.5 to 1000 nm
• Molar Mass Range by SLS - 1000 Da to 1 MDa^†
• Sensitivity (lysozyme 14.4 kDa) - 0.125 mg/mL

Fluidics

• Minimum Sample Volume - 4 µL (1536-well plate)

Optics

• Laser Wavelength - 830 nm
• Laser Power Control - Programmable 10% to 100%
• Sample Cell Options - 96-, 384- or 1536-well microwell plates. Industry standard disposable (choose from recommended list).
• Temperature Control - 4 to 85 °C

^†Upper limit depends on conformation: it is limited to a maximum R_h of 12 nm.

Description:

The Wyatt DynaPro PlateReader III is built for labs that need higher-throughput dynamic light scattering without the bottleneck of one-sample-at-a-time measurements. Designed as a plate-based DLS and SLS platform, it allows users to characterize proteins, nanoparticles, and other macromolecules directly in microwell plates, with measurements performed in situ after dispensing to help maximize throughput and reduce sample carryover. Wyatt positions the system for formulation development, stability studies, nanoparticle characterization, and other screening workflows where speed and reproducibility matter. 

This type of system is especially well suited for groups working in biotherapeutics, nanoparticle formulation, drug discovery, and viral and non-viral gene vectors.. 

The DynaPro Plate Reader III is designed to support a broad range of demanding analytical workflows while improving ease of use, throughput, reproducibility, and experimental flexibility. Common applications include aggregation and oligomerization studies, AAV titer analysis across multiple process stages, evaluation of protein stability parameters such as thermal denaturation and colloidal stability, protein crystallization optimization, and screening of high-concentration protein formulations for reversible self-association and viscosity-related behavior.

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